[Dysphagia] Reflux Medication Side Effects-Movement Disorders

[scott-dailey at uiowa.edu (Dailey, Scott)]

I have seen these effects in diabetics who have significant neuropathy.  It has resultedin in dysphagia, dysarthria, and impaired limb function.  One women was at the point where she was refusing all medical intervention because she was not able to do anything for herself.  I recommended a palliative care consult.  The palliative care physician recognized the Reglan problem.  Med was discontinued and the women's functioning and her mood completely changed.  (I am assuming her mood/outlook improved as a result of her improved functioning).

Scott Dailey
Speech-Language Pathologist
University of Iowa Hospitals and Clinics

-----Original Message-----
From: dysphagia-bounces@b9.com [mailto:dysphagia-bounces@b9.com]On
Behalf Of Irene Campbell-Taylor
Sent: Monday, August 02, 2004 2:07 PM
To: SuzMorris@aol.com; Dysphagia@b9.com
Subject: Re: [Dysphagia] Reflux Medication Side Effects-Movement
Disorders


Suzanne
Thank you for this. I have been trying to persuade physicians and others for years of the potentially devastating effects of these drugs on both young children and the elderly. In particular, domperidone, which is reputed not to cross the blood brain barrier, most certainly does, especially in adults and children who are, for whatever reason, neurologically vulnerable.
Irene.

SuzMorris@aol.com wrote:
There is a recent journal article on the development of movement disorders 
(i.e. tardive dyskinesia and other extrapyramidal signs) as side effects of 
neuroleptic medications such as Reglan. It is a detailed and excellent summary 
that provides extensive listings of symptoms to look for when a child (or adult) 
is given one of these medications for reflux. There is a downloadable PDF 
document of the entire article that is worth copying and sharing with clients, 
parents and physicians.


http://www.reflux.org/reflux/paghomfa.nsf/159edf97224144f98525691f00011fe4/2d3cd19e4757ae5b85256ea8001975f5?OpenDocument

Anderson EP, Freeman EB. Recognition of movement disorders: extrapyramidal 
side effects and tardive dyskinesias - Would you recognize them if you see them?
Practical Gastroenterology, 2004; 28(5): 14-26.

Abstract:
Anti-emetic, anti-spasmodic and prokinetic medications commonly used in 
gastroenterology are neuroleptics, a class of drugs which includes anti-psychotics 
used for schizophrenia. These medications are capable of causing serious and 
potentially permanent side effects. The manifestation of neuroleptic drug side 
effects may range from dramatic and debilitating to very subtle. It has been 
demonstrated repeatedly that these side effects often go unrecognized. Doctors 
prescribing prokinetics, anti-emetics and anti-spasmodics need to be able to 
recognize these side effects. A full description of the most common movement 
side effects and the corresponding medical term is included as a resource list 
for professionals and patients.



Suzanne Evans Morris, Ph.D.
New Visions
1124 Roberts Mountain Rd.
Faber, VA 22938
(434) 361-2285 ext. 5
www.new-vis.com
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Dr I Campbell-Taylor
Clinical Neuroscientist
Exclusive Distributor:
www.interactivetherapy.com
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